The mode of preparations of herbal medicine from selected plants for management of diseases has remained a major challenge in the Sunyani Municipality. The aim of this research is investigate the methods used in preparing herbal medicine. A mixed method approach was employed in collecting both qualitative and quantitative data using questionnaires, interview schedule and focus group discussions. In all, 115 respondents were randomly selected from the study community. Descriptive statistics were used in the analysis of quantitative data. Quotations and recorded voices were used in analyzing the qualitative data. Findings from the study show that the mode of herbal medicine preparations were decoction, concoction, extraction and grinding. Again, liquid, solid and ointments are the forms of prepared herbal medicine. The study recommends that the government, Ministry of Health and the Ghana Health Services should provide scientific processing equipment for herbal medicine preparation.